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Multiple Sclerosis and Hyperbaric Oxygen Therapy
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MULTIPLE SCLEROSIS DISEASE MODELS |
THEORIES ABOUT THE CAUSES OF MULTIPLE SCLEROSIS Over time, research into the unsolved mystery of multiple sclerosis has suggested viral, toxic environmental, or autoimmune triggers. Research has never isolated any infectious agent-bacterium or virus-from the brains of MS patients, so the disease is not considered contagious. Currently accepted U.S. theory is that multiple sclerosis is an autoimmune disease, perhaps activated by a virus and having genetic and gender components. Although current U.S. treatments are based on this model, there is no known cure.
Following this last theory, the immune response in MS may vary due to how quickly the body recognizes invading microbes, myelin, or other particulate ingested material as a threat and how quickly it mobilized the protective response of the endothelial cells. Endothelial cells, which line the blood vessels, are inefficient in bactericidal activity. The lymphocytes in the blood may also vary in their ability to produce the appropriate antibodies—this variability in response may explain a genetic basis for disease susceptibility, as well as how severely an individual is affected. Advanced imaging and electrophysiologic techniques challenge the traditional concept of MS being either a relapsing/remitting disease eventually becoming progressive or a chronic progressive from the onset. Chataway’s research suggests that MS never sleeps—that it is always chronically progressive pathologically, if not clinically.
And the latest tests suggest... SPECT (Single Photon Emission Computed Tomography) scans, which create images showing how blood flows within the body, suggest that the central nervous system lesions may be caused by lack of oxygen. In particular, much observed damage (sclerosis) appears to be focused around the small venules leading away from capillaries. The location of this damage raises one more question about the as-yet-undetermined cause of multiple sclerosis.
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